師資
個(gè)人簡(jiǎn)介
傅暘，博士，南方科技大學(xué)醫(yī)學(xué)院生物化學(xué)系正高級(jí)研究員/長(zhǎng)聘副教授，博士生導(dǎo)師，國(guó)家海外高層次青年人才，深圳市孔雀人才?，F(xiàn)任南方科技大學(xué)生物安全平臺(tái)副主任、冷凍電鏡委員會(huì)委員。2013年獲南開大學(xué)生物化學(xué)與分子生物學(xué)博士學(xué)位、哈佛大學(xué)醫(yī)學(xué)院聯(lián)合培養(yǎng)微生物學(xué)博士。師從世界著名微生物學(xué)家、美國(guó)科學(xué)院院士John Mekalanos教授。
本團(tuán)隊(duì)的科研工作方向可以總結(jié)為‘圍繞一個(gè)核心，開拓一條新線’。一個(gè)核心：即變形菌門細(xì)菌的大分子跨膜遞送系統(tǒng)相關(guān)蛋白和遺傳元件的功能機(jī)制解析與應(yīng)用研究；一條新線是指作為醫(yī)學(xué)院早期少數(shù)的微生物領(lǐng)域PI，我們響應(yīng)國(guó)家與學(xué)校號(hào)召開展的：新冠與猴痘病毒等新發(fā)突發(fā)傳染病病原的應(yīng)急攻關(guān)科學(xué)研究。聚焦在細(xì)菌大分子跨膜遞送這個(gè)研究核心，我們以弧菌、假單胞菌、氣單胞菌等細(xì)菌的II型、III型和VI型分泌系統(tǒng)及其效應(yīng)蛋白研究對(duì)象，面向：1）精準(zhǔn)抗菌機(jī)制與機(jī)理；2）致病性與宿主防御；3）相關(guān)應(yīng)用技術(shù)，展開了深入而系列化研究。同時(shí)，通過(guò)前期在‘病原蛋白與宿主互作’領(lǐng)域的理論與技術(shù)積累，我們?cè)谛掳l(fā)病毒研究的這條輔線中，面向抗體與藥物靶點(diǎn)研究，也已形成了自己的科研特色。目前傅暘團(tuán)隊(duì)累計(jì)發(fā)表研究論文37篇（南科大29篇)，其中入職前在Cell Host & Microbe、PNAS等雜志發(fā)表論文多篇，入職后以通訊作者（含共同）身份發(fā)表論文14篇，包括Mol Cell, Gut Microbes, J Biol Chem(2篇), Microbiol Res (2篇)，mLife, Virology, Allergy等，全部以南科大為本人唯一署名單位。論文總引超5620次。
本團(tuán)隊(duì)累計(jì)主持國(guó)家自然科學(xué)基金委面上項(xiàng)目和青年項(xiàng)目、深圳市科創(chuàng)委基礎(chǔ)研發(fā)重點(diǎn)專項(xiàng)、深圳市科創(chuàng)委孔雀團(tuán)隊(duì)項(xiàng)目、深圳市抗疫應(yīng)急攻關(guān)重點(diǎn)專項(xiàng)、深圳市醫(yī)學(xué)科學(xué)院（SMART）等十余項(xiàng)項(xiàng)目。
學(xué)術(shù)任職
1、Bio-Protocol雜志編輯
2、Frontiers Cellular and Infection Microbiology專刊編輯
獲獎(jiǎng)榮譽(yù)
1、國(guó)家級(jí)人才頭銜
2、深圳市人才頭銜
3、Fogarty Global Health Fellowship
教育經(jīng)歷
1、2001.09-2005.06 江南大學(xué)，生物工程學(xué)專業(yè)學(xué)士
2、2006.09-2013.06 南開大學(xué)，生物化學(xué)與分子生物學(xué)專業(yè)博士
3、2009.09-2013.05 哈佛大學(xué)，微生物學(xué)與免疫生物學(xué)專業(yè)聯(lián)培博士
工作經(jīng)歷：
1、2005.07-2006.08 南開大學(xué)，技術(shù)員
2、2008.06-2009.01 哈佛大學(xué)公共衛(wèi)生學(xué)院，交換生
3、2013.07-2018.06 哈佛大學(xué)醫(yī)學(xué)院，博士后研究員
4、2018.07-2019.06 哈佛大學(xué)醫(yī)學(xué)院，助理研究員
5、2019.06-2020.12 南方科技大學(xué)，助理教授/博士生導(dǎo)師
6、2021.01-至今 南方科技大學(xué)，副教授/博士生導(dǎo)師
代表性論文：
* Contributed equally to the work and # for corresponding authors
Representative papers at SUSTech as a Corresponding author:
(1) Liu M, Wang H, Wang Z, Wang H, Zhang K, Xue J, Liu RH, Liu Y, Xia PY, Wang H, Kan B, Li Y, Li S, Fu Y#. A Vibrio-specific T6SS effector reshapes microbial competition by disrupting Vibrio bioenergetics, a precision antimicrobial mechanism. Cell Host and Microbe. 2025, in press.
(2) Wang H, Liu Y, Wang Z, Xia P, Li Z, Liu M#, Fu Y#. Functional Insights into the Type VI Secretion System of Multi-drug Resistant Aeromonas hydrophila: A Key Factor in Competition and Pathogenesis. mLife. 2025, in press. DOI: 10.1002/mlf2.70018.
(3) Guo HH, Zhang Q, Wang Z, Zhang K#, Fu Y#. Structural insight into Vibrio cholerae EIIC Sugar Transporter Dimer Captured in a Substrate-Free Inward-facing State. Acta Biochimica et Biophysica Sinica. 2025, in press.
(4) Feng Q*, Dai, X, Wu, Q, Zhang L#, Yang L#, Fu Y#. C-di-GMP phosphodiesterase ProE interacts with quorum sensing protein PqsE to promote pyocyanin production in Pseudomonas aeruginosa. mSphere. 2025; e01026-24.
(5) Yu B*, Lu Q*, Li J*, Cheng X*, Hu H, Li Y, Che T, Hua Y, Jiang H, Zhang Y, Xian C, Yang T, Fu Y, Chen Y, Nan W, McCormick PJ, Xiong B, Duan J, Zeng B, Li Y#, Fu Y#, Zhang J#. Cryo-EM structure of human HCN3 channel and its regulation by cAMP. J Biol Chem. 2024;300(6):107288.
(6) Xiang Q*, Wu J, Zhou Y, Li L, Tian M, Li G#, Zhang Z#, Fu Y#. SARS-CoV-2 Membrane protein regulates the function of Spike by inhibiting its plasma membrane localization and enzymatic activity of Furin. Microbiol Res. 2024; 282:127659.
(7) Feng Q*, Zhou J, Zhang L, Fu Y#, Yang L#. Insights into the molecular basis of c-diGMP signalling in Pseudomonas aeruginosa. Crit Rev Microbiol. 2024;50(1):20-38.
(8) Zhang Y*, Wang D*, Xiang Q*, Hu X, Zhang Y, Wu L, Zhang Z, Wang Y, Zhao J, McCormick PJ, Fu J#, Fu Y#, Zhang J#, Jiang H#, Li J#. A potent neutralizing nanobodytargeting a unique epitope on the receptor-binding domain of SARS-CoV-2 spike protein. Virology. 2024; 589:109925.
(9) Liu M*, Wang H*, Liu Y, Tian M, Wang Z, Shu RD, Zhao MY, Chen WD, Wang H, Wang H, Fu Y#. The phospholipase effector Tle1(Vc) promotes Vibrio cholerae virulence by killing competitors and impacting gene expression. Gut Microbes. 2023; 15(1): 2241204.
(10) Liu M*, Zhao MY*, Wang H, Wang ZH, Wang Z, Liu Y, Li YP, Dong T, Fu Y#. Pesticin-Like Effector VgrG3(cp) Targeting Peptidoglycan Delivered by the Type VI Secretion System Contributes to Vibrio cholerae Interbacterial Competition. Microbiol Spectr. 2023; 11(1): e0426722.
(11) Zhang K*, Peng T*, Tao X*, Tian M*, Li Y, Wang Z, Ma S, Hu S, Pan X, Xue J, Luo J, Wu Q, Fu Y#, Li S#. Structural insights into caspase ADPR deacylization catalyzed by a bacterial effector and host calmodulin. Mol Cell. 2022;82(24):4712-4726 e4717.
(12) Xiang Q, Li L, Wu J, Tian M, Fu Y#. Application of pseudovirus system in the development of vaccine, antiviral-drugs, and neutralizing antibodies. Microbiol Res. 2022; 258:126993. [JCR: Q1].
(13) Song X*, Li J*, Tian M*, Zhu H, Hu X, Zhang Y, Cao Y, Ye H, McCormick PJ, Zeng B, Fu Y#, Duan J#, Zhang J#. Cryo-EM structure of mouse TRPML2 in lipid nanodiscs. J Biol Chem. 2022;298(2):10148.
(14) Chen Y*, Wang S*, Huang J*, Fu Y, Wen J, Zhou C, Fu Y#, Liu L#. Application of extracorporeal carbon dioxide removal combined with continuous blood purification therapy in ARDS with hypercapnia in patients with critical COVID-19. Clin Hemorheol Microcirc. 2021; 78(2):199-207. [JCR: Q3].
(15) Cai Q*, Huang D*, Ou P*, Yu H, Zhu Z, Xia Z, Su Y, Ma Z, Zhang Y, Li Z, He Q, Liu L#, Fu Y#, Chen J#. COVID-19 in a designated infectious diseases hospital outside Hubei Province, China. Allergy. 2020;75(7):1742-1752. [JCR: Q1].
Before joining SUSTech
(16) Fu Y*, Ho BT*, Mekalanos JJ#. Tracking Vibrio cholerae Cell-Cell Interactions during Infection Reveals Bacterial Population Dynamics within Intestinal Microenvironments. Cell Host and Microbe. 2018; 23(2): 274-281 e272.
(17) Ho BT*, Fu Y*, Dong TG, Mekalanos JJ#. Vibrio cholerae type 6 secretion system effector trafficking in target bacterial cells. Proc Natl Acad Sci USA. 2017;114(35):9427-9432.
(18) Fu Y, Waldor MK, Mekalanos JJ#. Tn-Seq analysis of Vibrio cholerae intestinal colonization reveals a role for T6SS-mediated antibacterial activity in the host. Cell Host and Microbe. 2013; 14(6): 652-663.