師資
許揚(yáng)，南科大醫(yī)學(xué)院副教授，博士生導(dǎo)師。于2015年博士畢業(yè)于美國(guó)貝勒醫(yī)學(xué)院，并在2015-2020年在美國(guó)北卡羅萊納大學(xué)教堂山分校完成博士后訓(xùn)練。從事癌癥CAR-T免疫治療和基礎(chǔ)免疫學(xué)研究。相關(guān)的研究發(fā)表于Nature Biotechnology, Blood，Journal of Clinical Investigation，Cancer Cell等國(guó)際頂級(jí)期刊。共發(fā)表論文8篇，總引用數(shù)575次（Google Scholar）并獲得兩項(xiàng)美國(guó)專利。
教育背景：
2006 – 2010 多倫多大學(xué) 免疫學(xué) 學(xué)士
2010 – 2015 貝勒醫(yī)學(xué)院 免疫學(xué) 博士
工作經(jīng)歷：
2015 – 2020 北卡大學(xué)教堂山分校 博士后
獲獎(jiǎng)情況及榮譽(yù)：
2016 Horizon Fellowship Award Department of Defense, 美國(guó)
研究領(lǐng)域：
主要從事CAR-T細(xì)胞在實(shí)體腫瘤中的應(yīng)用研究。通過研究實(shí)體腫瘤微環(huán)境中的分子細(xì)胞機(jī)制從而攻克CAR-T細(xì)胞在治療實(shí)體腫瘤過程中的難題。
研究的方向包括：
開發(fā)新型的趨化系統(tǒng)改善CAR-T細(xì)胞浸潤(rùn)實(shí)體腫瘤的能力。
研究CAR-T細(xì)胞耗竭過程的分子機(jī)制以及耗竭相關(guān)受體對(duì)CAR-T功能的影響。
優(yōu)化CAR-T細(xì)胞在腫瘤微環(huán)境中的代謝能力。
與此同時(shí)，課題組與美國(guó)多個(gè)實(shí)驗(yàn)室保持合作關(guān)系，將在T信號(hào)機(jī)制， T細(xì)胞分化等領(lǐng)域進(jìn)行合作。
學(xué)術(shù)任職：
Review Editorial Board - Frontier Immunology
Review Editorial Board - Frontier Oncology
Reviewer for Science Advanced, Cancer Cell, Cellular & Molecular Immunology, Cancer Immunology, Immunotherapy.
發(fā)表論文：
Xu Y, Zhang M, Ramos CA, Durett A, Liu E, Dakhova O, Liu H, Creighton CJ, Gee AP, Heslop HE, Rooney CM, Savoldo B, Dotti G. 2014. Closely related T-memory stem cells correlate with in vivo expansion of CAR.CD19-T cells and are preserved by IL-7 and IL-15. Blood 24: 3750-59
Xu Y, Chaudhury A, Zhang M, Savoldo B, Metelitsa LS, Rodgers J, Yustein JT, Neilson JR, Dotti G. 2016. Glycolysis determines dichotomous regulation of T cell subsets in hypoxia. Journal of Clinical Investigation 126(7):2678-88.
Xu Y, Dotti G. 2016. Selection bias: maintaining less-differentiated T cells for adoptive immunotherapy. Journal of Clinical Investigation 126(1):35-7.
Ma X, Shou P, Smith C, Chen Y, Du H, Sun C, Kren NP, Michaud D, Ahn S, Vincent B, Savoldo B, Pylayeva-Gupta Y, Zhang S, Dotti G, Xu Y. 2020. Interleukin-23 engineering improves CAR-T cell function in solid tumors. Nature Biotechnology.
Sun C, Shou P, Du H, HIrabayashi K, Chen Y, Herring L, Ahn S, Xu Y, Suzuki K, Li G, Tsahouridis O, Su L, Savoldo B, Dotti G. 2020. Themis-SHP1 Recruitment by 4-1BB Tunes LCK-Mediated Priming of Chimeric Antigen Receptor-Redirected T cells. Cancer Cell. 37, 1-10.
Du H, Hirabayashi K, Ahn S, Kren NP, Montgomery SA, Wang X, Tiruthani K, Mirlekar R, Michaud D, Greene K, Herrera SG, Sun C, Chen Y, Xu Y, Ma X, Ferrone CR, Pylayeva-Gupta Y, Yeh JJ, Liu R, Savoldo B, Ferrone S, Dotti G . 2019. Antitumor Responses in the Absence of Toxicity in Solid Tumors by Targeting B7-H3 Via Chimeric Antigen Receptor T Cells. Cancer Cell 35, 221–237.
Jones RB, Garrison KE, Mujib S, Mihajlovic V, Aidarus N, Hunter DV, Martin E, John VM, Zhan W, Faruk NF, Gyenes G, Sheppard NC, Priumboom-Brees IM, Goodwin DA, Chen L, Rieger M, Muscat-King S, Loudon PT, Stanley C, Holditch SJ, Wong JC, Clayton K, Duan E, Song H, Xu Y, SenGupta D, Tandon R, Sacha JB, Brockman MA, Benko E, Kovacs C, Nixon DF, Ostrowski MA. 2012. HERV-K-specific T cells eliminate diverse HIV-1/2 and SIV primary isolates. Journal of Clinical Investigation 12: 4473-89.
Jones RB, Song H, Xu Y, Garrison KE, Buzdin AA, Anwar N, Hunter DV, Mujib S, Mihajlovic V, Martin E, Lee E, Kuciak M, Raposo RA, Bozorgzad A, Meiklejohn DA, Ndhlovu LC, Nixon DF, Ostrowski MA. 2013. LINE-1 retrotransposable element DNA accumulates in HIV-1-infected cells. Journal of Virology 24:13307-20.