師資
個(gè)人簡(jiǎn)介：
蘇楊博士，南方科技大學(xué)生命科學(xué)學(xué)院研究助理教授，江蘇海洋大學(xué)學(xué)士，南京師范大學(xué)生物學(xué)博士，上海交通大學(xué)和南方科技大學(xué)博士后。主要研究磷酸肌醇的功能和蛋白質(zhì)穩(wěn)態(tài)的代謝調(diào)控。獲國(guó)家自然科學(xué)基金青年項(xiàng)目、廣東省自然科學(xué)基金面上項(xiàng)目、深圳市基礎(chǔ)研究面上項(xiàng)目資助。以第一作者或共第一作者在Molecular Cell，mbio，F(xiàn)EBS Journal等雜志上發(fā)表研究論文多篇。入選深圳市高層次人才計(jì)劃。
研究領(lǐng)域：
Culling-ING ligase(CRL)泛素連接酶是最大的E3泛素連接酶群體，介導(dǎo)體內(nèi)總泛素化的20%。CRLs需要被擬素化修飾激活才能行使功能，受去擬素酶CSN復(fù)合體抑制。我們研究CRL擬素化的代謝分子調(diào)控路徑，包括多磷酸肌醇小分子和營(yíng)養(yǎng)。
工作經(jīng)歷：
2021.11 - 至今，南方科技大學(xué)，神經(jīng)生物學(xué)系，研究助理教授
2018.12 - 2021.7，南方科技大學(xué)，神經(jīng)生物學(xué)系，博士后，合作導(dǎo)師：饒楓副教授
2016.07 - 2018.09，上海交通大學(xué)醫(yī)學(xué)院，微生物與免疫學(xué)學(xué)系，博士后，合作導(dǎo)師：姚玉峰教授
學(xué)習(xí)經(jīng)歷：
2011.09 - 2016.06，南京師范大學(xué)，生命科學(xué)學(xué)院，博士，導(dǎo)師：黃鷹教授
2007.09 - 2011.06，江蘇海洋大學(xué)，海洋學(xué)院，學(xué)士
代表文章：
(1) Yang Su(#), Yifan Luo(#), Peitao Zhang, Hong Lin, Weijie Pu, Hongyun Zhang, Huifang Wang, Yi Hao, Yihang Xiao, Xiaozhe Zhang, Xiayun Wei, Siyue Nie, Keren Zhang, Qiuyu Fu, Hao Chen, Niu Huang, Yan Ren, Mingxuan Wu, Billy Kwok Chong Chow, Xing Chen, Wenfei Jin, Fengchao Wang*, Li Zhao*, Feng Rao*, Glucose-induced CRL4COP1-p53 axis amplifies glycometabolism to drive tumorigenesis, Molecular Cell, 2023 Jun 6;83(13):2316-2331.
(2) Yang Su(#), Jianhui Li(#), Wenting Zhang(#) Jinjing Ni, Rui Huang, Zuoqiang Wang, Sen Cheng, Yue Wang, Zhixin Tian, Qiuxiang Zhou, Donghai Lin, Wenjuan Wu, Christoph M. Tang, Xiaoyun Liu*, Jie Lu*, Yu-Feng Yao*, Methylation of PhoP by CheR regulates Salmonella virulence, mBio. 2021 Sep 21; e0209921. doi: 10.1128/mBio.02099-21.
(3) Su Y, Yang Y, Huang Y(*), Loss of ppr3, ppr4, ppr6 or ppr10 perturbs iron homeostasis and leads to apoptotic cell death in Schizosaccharomyces pombe, FEBS J, 2017, 284(2): 324-337.
(4) Su Y(#), Chen C(#), Huang L(#), Yan J, Huang Y(*), Schizosaccharomyces pombe Homologs of Human DJ-1 Are Stationary Phase Associated Proteins That Are Involved in Autophagy and Oxidative Stress Resistance, PloS One, 2015, 10(12): e0143888.
(5) Zhao Q(#), Su Y(#), Wang Z(#), Chen C, Wu T, Huang Y(*), Identification of glutathione (GSH)-independent glyoxalase III from Schizosaccharomyces pombe, Bmc Evol Biol, 2014, 14: 86.
(6) Su Y, Chen J, Huang Y(*), Disruption of ppr3, ppr4, ppr6, or ppr10 induces flocculation and filamentous growth in Schizosaccharomyces pombe, FEMS Microbiol Lett, 2018 Aug 1;365(16).
(7) Ren J(#), Sang Y(#), Qin R, Su Y, Cui Z, Mang Z, Li H, Lu S, Zhang J, Cheng S, Liu X, Li J, Lu J, Wu W, Zhao GP, Shao F, Yao YF(*), Metabolic intermediate acetyl phosphate modulates bacterial virulence via acetylation, Emerg Microbes Infect, 2019;8(1):55-69.
(8) Rao F(*), Lin H, Su Y, Cullin-RING Ligase Regulation by the COP9 Signalosome: Structural Mechanisms and NewPhysiologic Players, Adv Exp Med Biol, 2020;1217:47-60.
(9) Lin H(#), Zhang X(#), Liu L(#), Fu Q, Zang C, Ding Y, Su Y, Xu Z, He S, Yang X, Wei X, Mao H, Cui Y, Wei Y, Zhou C, Du L, Huang N, Zheng N, Wang T*, Rao F*, Basis for metabolite-dependent Cullin-RING ligase deneddylation by the COP9 signalosome, Proceedings of the National Academy of Sciences, 2020 Feb 25;117(8):4117-4124.
(10) Xiaozhe Zhang, Shaodong Shi, Yang Su, Xiaoli Yang, Sining He, Jing Wu, Jian Zhang, Feng Rao*, Suramin and NF449 Are IP5K Inhibitors That Disrupt IP6-mediated Regulation of Cullin RING Ligase and Sensitize Cancer Cells to MLN4924/pevonedistat, J Biol Chem, 2020 Jun 3;jbc.RA120.014375.
(11) Jianhui Li(#), Shuting Liu(#), Yang Su, Jie Ren, Yu Sang, Jinjing Ni, Jie Lu, Yu-Feng Yao*, Acetylation of PhoP K88 is involved in regulating Salmonella virulence, Infect Immun, 2020 Dec 14;IAI.00588-20.
(12) Hong Lin(#), Yuan Yan(#), Yifan Luo(#), Wing Yan So(#), Xiayun Wei, Xiaozhe Zhang, Xiaoli Yang, Jun Zhang, Yang Su, Xiuyan Yang, Bobo Zhang, Kangjun Zhang, Nan Jiang, Billy Kwok Chong Chow, Weiping Han, Fengchao Wang & Feng Rao*, IP6 -assisted CSN-COP1 competition regulates a CRL4-ETV5 proteolytic checkpoint to safeguard glucose-induced insulin secretion against hyperinsulinemia, Nature Communications, 2021 Apr 28;12(1):2461.
(13) Yifan Luo, Yang Su & Feng Rao*, Role of NEDD8 and neddylation dynamics in DNA damage response, Genome Instability & Disease, 2021, volume 2, pages139–149.