個(gè)人簡(jiǎn)介
周曉輝，南方科技大學(xué)教授、博士生導(dǎo)師，入選國家高層次人才計(jì)劃。2008年獲華盛頓州立大學(xué)微生物學(xué)博士，曾擔(dān)任美國康涅狄格大學(xué)病原生物學(xué)系終身教授，疫苗研究中心研究員（Principal Investigator）。已發(fā)表論文80余篇，其中通訊作者論文30余篇（包括PNAS，EMBO J，Nature Communications，Biomaterials, PLoS Pathogens等國際一流期刊）。曾主持多個(gè)美國NIH R01項(xiàng)目及美國農(nóng)業(yè)部項(xiàng)目，獲總額300余萬美元資助，授權(quán)多個(gè)國內(nèi)國際專利?，F(xiàn)任微生物學(xué)領(lǐng)域知名期刊Microbiological Research 主編（Editor-in-Chief），長期受邀擔(dān)任包括EMBO J, eLife, mBio, Biomaterials等多個(gè)國際一流期刊審稿專家。
研究方向
1. 病原微生物與宿主互作及致病的分子機(jī)制
2. 感染性疾病疫苗的開發(fā)與研究
3. 抗生素耐藥機(jī)制及新型抗感染藥物的開發(fā)
工作經(jīng)歷
2022 – 至今： 南方科技大學(xué) 教授
2013 – 2022：美國康涅狄格大學(xué)病原生物系 助理教授、副教授、終身教授、研究員 (PI)
2010 – 2013：哈佛大學(xué)醫(yī)學(xué)院/HHMI 研究助理
2008 – 2010：美國華盛頓州立大學(xué) 博士后
代表性論文（#共同一作，*通訊作者）
1. Huang M, Wang Z, Yao L, Zhang L, Gou X, Mo H, Li H, Hu L, Zhou X*. Ferric chloride induces ferroptosis in Pseudomonas aeruginosa and heals wound infection in a mouse model. Int J Antimicrob Agents. 2023, 61(5):106794.
2. Wang Z, Li H, Zhou W, Lee J, Liu Z, An Z, Xu D, Mo H, Hu L, Zhou X*. Ferrous sulfate-loaded hydrogel cures Staphylococcus aureus infection via facilitating a ferroptosis-like bacterial cell death in a mouse keratitis model. Biomaterials 2022, 290:121842.
3. Hu M, Zhang Y, Gu D, Chen X, Waldor MK and Zhou X*. Nucleolar c-Myc recruitment by a Vibrio T3SS effector promotes host cell proliferation and bacterial virulence. The EMBO J. 2021, 15;40(2): e105699.
4. Gu D, Zhang Y, Wang Q and Zhou X*. S-nitrosylation mediated activation of a histidine kinase represses T3SS1 gene expression and promotes virulence of an enteric pathogen. Nat. Commun. 2020, 11:5777.
5. Hu M, Zhang H, Gu D, Ma Y and Zhou X*. Identification of the first tail tubular proteins receptor that mediates phage adsorption to a marine pathogen Vibrio parahaemolyticus. Emerging Microbes & Infections. 2020. 9:855-867.
6. Gu D, Yang M, Zhang Y, Zhou X*, and Wang*. A σE-mediated temperature gauge controls a switch from LuxR-mediated virulence gene expression to thermal stress adaptation in Vibrio alginolyticus. PLoS Pathogens. 2016, 2; 12(6): e1005645.
7. Li L, Wang, Zhang H, Kahn K and Zhou X*. A sensor histidine kinase is a beta-lactam receptor and induces resistance to beta-lactam. PNAS. 2016,113 (6):1648-1653. (Highlighted by Nature Review Microbiology: https://www.nature.com/articles/nrmicro.2016.27)
8. Zhou X, Gewurz BE, Ritchie JM, Takasaki K, Davis BM, and Waldor MK. A Vibrio parahaemolyticus type III effector mediates pathogenesis by independently enabling intestinal colonization and inhibiting TAK1 activation. Cell Reports. 2013 30:1690-702.
